Pharmacokinetics of 99mTc-MAA- and 99mTc-HSA-Microspheres Used in Preradioembolization Dosimetry: Influence on the Liver–Lung Shunt
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چکیده
منابع مشابه
Absent pulmonary uptake on 99mTc MAA perfusion lung scan due to severe right-to-left shunt.
c 5 XTRAPULMONARY accumulation of Tc macroaggregated albumin (MAA) is rarely een on perfusion lung scan, and has been reported n less than 4% of a study population of nearly 380 atients.1 It occurs when the agent bypasses the ungs due to a right-to-left (R-L) cardiac or pulonary shunt, when it is shunted to the portal vein efore reaching the right atrium and ventricle of he heart, and when the ...
متن کاملMicrospheres Used in Pre-Radioembolization Dosimetry: Influence on the Liver–Lung Shunt Running title: Albumin Microspheres in Radioembolization
1 Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany 2 Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany 3 2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland 4 pharmtrace clinical research, Berlin, Germany Corresponding Author: Oliver Stephan Grosser Department of Radiology and Nuclear Medicine Uni...
متن کاملPrognostic utility of 90Y radioembolization dosimetry based on fusion 99mTc-macroaggregated albumin-99mTc-sulfur colloid SPECT.
UNLABELLED Planning hepatic (90)Y radioembolization activity requires balancing toxicity with efficacy. We developed a dual-tracer SPECT fusion imaging protocol that merges data on radioactivity distribution with physiologic liver mapping. METHODS Twenty-five patients with colorectal carcinoma and bilobar liver metastases received whole-liver radioembolization with resin microspheres prescrib...
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BACKGROUND Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been p...
متن کاملOxygen and 99mTc-MAA shunt estimations in patients with pulmonary arteriovenous malformations: effects of changes in posture and lung volume.
BACKGROUND Patients with arteriovenous malformations are routinely monitored with arterial oxygen saturation (SaO2) estimations (breathing air) from which an oxygen shunt fraction can be calculated. This simple estimation has been compared with an anatomically defined estimate of the right to left shunt using a radioisotopic method. The fall in SaO2 which occurs in patients with pulmonary arter...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2016
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.115.169987